Optimal experimental design in an EGFR signaling and down-regulation model

Fergal P. Casey, Dan Baird, Qiyu Feng, Ryan N. Gutenkunst, Joshua J. Waterfall, Christopher R. Myers, Kevin S. Brown, Richard A. Cerione, James P. Sethna 1 Center for Applied Mathematics, Cornell University, Ithaca, NY 14853, USA Department of Cellular and Molecular Medicine and the Howard Hughes Medical Institute, University of California at San Diego, La Jolla, CA 92093, USA Department of Molecular Medicine, College of Veterinary Medicine, Cornell University, NY 14853, USA 4 Laboratory of Atomic and Solid State Physics, Cornell University, Ithaca, NY 14853, USA Cornell Theory Center, Cornell University, Ithaca, NY 14853, USA and Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA